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Giants vs. Rams predictions, odds, time: Week 2 ‘Monday Night Football’ picks, NFL best bets by proven model

September 22, 2026 • 2 min read

All eyes turn to SoFi Stadium in Inglewood this Monday night as the New York Giants travel west to face the Los Angeles Rams in a highly anticipated Week 2 clash. The Giants enter the contest riding a wave of momentum following a gritty 28-20 victory over the Dallas Cowboys, led by quarterback Jaxson Dart who looked sharp in his opener with three touchdown passes. On the other side, the Rams are looking to bounce back from a disappointing loss to the San Francisco 49ers during their international trip to Melbourne.

Personnel shifts will play a major role in how this game unfolds. Los Angeles welcomes back defensive powerhouse Aaron Donald, but they will be missing key contributors like Myles Garrett, who was recently placed on injured reserve with a knee injury, and standout receiver Puka Nacua, who is officially inactive due to a hip issue. Despite these losses, the oddsmakers still view the Rams as the favorites, setting them at 6.5 points ahead of New York with an over/under total of 47.5 points.

For those looking toward the betting markets, data models suggest high scoring might be the story of the evening. A simulation model from SportsLine, which runs thousands of iterations per game, is leaning toward the over on total points. This prediction aligns with recent history, as both teams have trended toward higher scores in their most recent outings and their previous head-to-head matchups often result in offensive fireworks.

While Matthew Stafford had a slower start to this campaign compared to his dominant MVP season last year, his track record makes him a constant threat against any defense. With running back Cam Skattebo providing a physical ground presence for New York and Stafford leading an explosive L.A. air attack, fans can expect plenty of action when kickoff arrives at 8:15 p.m. ET on Monday night football.

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